Singapore's Catch-22

Clinical Notes CATCH 22 Syndrome

CATCH 22 syndrome is characterized by cardiac defects, abnormal facial features, thymic hypoplasia, cleft palate, and hypocalcemia. It is associated with a deletion within chromosome 22q11. This syndrome is not a simple disease. It includes DiGeorge syndrome, conotruncal anomaly face syndrome, and velocardiofacial syndrome. In DiGeorge’s original report, he focused on thymic hypoplasia and hypo...

Referenda as a Catch-22

The result of a referendum delivers a signi…cant amount of information about social preferences to each composite member of the society. This paper argues that, beyond this obvious fact, the choice not to o¤er a referendum by an authority, although permitted to do so, may enhance as well the information individuals posses about social preferences. The addition of a referendum option in the rule...

Platelet genomics beats the catch-22.

advantages such as a larger cargo load ( 14 kb, allowing the inclusion of more genes or larger regulatory elements), different insertion preferences, and the exclusive use of TTAA target sequence.2-4 For some applications, the PB transposition offers an additional advantage: the integrated transposon can be precisely excised by re-expression of PB transposase transiently as shown by several gro...

Resolving a catch-22 in cardiac gene regulation.

You have a big heart.” These five words have almost as many implications. Being big hearted can describe a generous and giving nature. In a different context, Secretariat’s heart was unusually large because he carried an X-linked gene1 conferring on him rare physiological attributes that in 1973 propelled him to thoroughbred horse racing’s Triple Crown. When the same declaration occurs between ...

Kenny-Caffey syndrome without the CATCH 22 deletion.